Date of Award

May 2024

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Binglin Sui

Abstract

Fluoroionophore for ionic and neutral analytes are extensively used in a number of fields for example: pharmacology, physiology, biology, and environmental sciences. The concept of this fluoroionophore in other word fluorescent chemo sensor has been used in the past 150 years. In recent years, a wide range of fluoroionophores have been developed for the detection of chemical species which are important for environment and biology. Instead of the progress, still there are challenges and problems in this area of research. This thesis addresses novel sensors for the measurement of biologically important cations. The sensors are based on fluoroionophores which shows characteristic spectral properties when interacts with ions. The fluoroionophore contains two building units: the chromophore and the receptor. Usually, receptors are based on an azacrown ether which behaves as the recognition unit for metal cations and capable of quenching the fluorescence of the chromophore by photoinduced electron transfer (PET) mechanism. When ionophore interacts with ions, PET is inhibited which leads to an increase of fluorescence that is determined by the chromophore. Both building units of the fluoroionophore can be modified independently which allows a modular design of new sensing molecules. The flexibility of this concept is established by preparing a new BODIPY dyes with adjustable photophysical properties and varied crown-ethers with selective cation sensitivity. In this thesis we have synthesized a series of ionophore which a selective for particular cation and combining with BODIPY will leads to a complete fluoroionophor.

Download

Share

COinS