Date of Award

1-3-2003

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

First Advisor

Jody A Rada

Abstract

Changes in scleral extracellular matrix, which is composed of proteins including glycoproteins, proteoglycans, and collagen, allow axial elongation of the eye resulting in myopia. Theoretically, changes in any scleral component could result in changes leading to increased axial length. The purpose of this study is to characterize and study the function of one protein found in scleral extracellular matrix, lumican.

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