Download

Download Full Text (289 KB)

Document Type

Poster

Description

Pediatric laceration repair is a common, yet anxiety-inducing procedure for those who must undergo them. With limited research analyzing the different types of pre-procedural anxiolytic medications, the purpose of this research and literature review was to explore two distinct but commonly used intranasal (IN) anxiolytics, dexmedetomidine and midazolam, and to compare their efficacy, adverse effects, and overall pediatric anxiety and parental satisfaction. Databases including PubMed, GoogleScholar, and ClinicalKey were searched to find articles investigating clinical trials using pediatric participants. Meta-analyses, animal studies, dental procedures, imaging procedures, full sedation procedures, and ongoing studies were excluded. In terms of effective anxiolysis, intranasal dexmedetomidine (IND) 2 or 3 ug/kg should be considered the preferred IN medication for pediatric laceration repair procedures as it significantly reduced anxiety levels and increased parental satisfaction scores without having any reported significant adverse effects. Counteractively, administration of intranasal midazolam (INM) 0.4 mg/kg 5mg/mL solution revealed a decrease in pediatric anxiety but imposed vomiting adverse effects. Future studies regarding IND’s bioavailability, pharmacokinetics, and optimal doses per age or weight group could be considered for further supportive evidence.

Department

Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

Date of Work

2025

Publication Date

Spring 5-2025

Keywords

pediatric, children, laceration repair, suture, anxiolytic, administration intranasal, intranasal midazolam, intranasal dexmedetomidine, emergency treatment, parent satisfaction

Disciplines

Medicine and Health Sciences

Pre-Procedural Anxiolytic Use in Pediatric Laceration Repair

Share

COinS