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Document Type

Poster

Description

During perimenopause, women are at increased risk of depression due to complex and multifactorial factors, such as HPA axis dysregulation and fluctuations in hormones, like estradiol. Antidepressants are currently used to treat depression, but hormone replacement therapy may also have comparable antidepressant effects based on hormonal mechanisms. Perimenopausal depression is a unique subtype of depression and needs to be routinely screened by OBGYNs and primary care providers. The literature review found mixed results on the efficacy of HRT, antidepressants, and a combination of both; all treatments have shown promising benefits and specific screening may be needed to tailor treatment.

Department

Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

Publication Date

Spring 2023

Keywords

menopause transition (MT), perimenopause, depression, antidepressants, hormone replacement therapy, estradiol fluctuation, depression screening, hormones, perimenopausal depression, SSRIs, climacteric

Disciplines

Medicine and Health Sciences

Perimenopausal Depression Screening and Treatment Efficacy Between Antidepressants and/or Hormone Replacement Therapy

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