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Document Type
Poster
Description
• Chronic obstructive pulmonary disease (COPD) is a progressive disease that has no cure but is treatable. The treatment goal is to have adequate symptom control, decreased exacerbations, prevent hospitalizations and maintain an independent quality of life.
• The review of literature is to determine if the benefits of long-term antimicrobial therapy outweigh the risks in the treatment of severe COPD.
• The gold standard for pharmacotherapy consists of inhaled corticosteroids and bronchodilators (long-acting beta2agonist (LABA).
• Adding azithromycin to standard therapy for patients with frequent exacerbations showed a 27% reduction in exacerbation frequency.
• With prolonged use of antimicrobials there is an increased risk of bacterial resistance. However, in doing this research, it was found that bacterial resistance was not noticed between azithromycin (52%) versus placebo (57%), p = 0.64.
• Although long-term antimicrobial therapy is becoming a hot topic, it is imperative that we continue to study the detrimental development of bacterial resistance.
Department
Physician Assistant Studies
Degree Name
Master of Physician Assistant Studies (MPAS)
Publication Date
2018
Keywords
chronic obstructive pulmonary disease; antibiotics; macrolides; antibacterial; azithromycin; bronchodilators; standard therapy; COPD exacerbations; adverse effects
Disciplines
Pulmonology
Recommended Citation
Trautner, Jamie, "Antibiotic Therapy in Preventing Exacerbations of Severe Chronic Obstructive Pulmonary Disease" (2018). Physician Assistant Scholarly Project Posters. 27.
https://commons.und.edu/pas-grad-posters/27