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• Type II diabetes mellitus (T2DM) affects hundreds of millions of individuals in the United States and prevalence is increasing. • As a lifelong disease, interventions must be studied long-term. • This project aims to compare long term efficacity of Roux-en-Y gastric bypass surgery and several antidiabetic medications that result in weight loss in type II diabetics who have failed to achieve goals through first line treatment of diet, exercise, and metformin. • A literature review was completed using the electronic search database PubMed with a variety of MeSH terms and keywords. • Research showed strong evidence that surgery was superior to medications in reducing HbA1C and weight. • Research also showed that the antidiabetic medications discussed decreased HbA1C and weight superiorly to placebos and other classes of antidiabetic medications. • Continued research that directly compares these medications over a longer interval of time is needed.


Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

First Advisor

Kauffman, Russell

Publication Date

Spring 2023


long term, gastric bypass, weight loss medication


Medicine and Health Sciences

Long Term Control of T2DM and Weight Through Roux-en-Y Gastric Bypass Surgery Versus Weight Loss Medication