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Metformin is commonly used to decrease insulin resistance and increase fertility in women with PCOS. However, it is known to cause many side effects. Myoinositol is a B-vitamin that is thought to also decrease insulin resistance and increase fertility with few side effects. The purpose of this literature review is to determine whether myoinositol is a comparable substitute for metformin in patients with PCOS suffering with infertility. This was done by evaluating pregnancy rates, insulin resistance, and side effects of metformin and myoinositol. A literature review found that both medications had similar pregnancy rates. Neither medication affected insulin resistance. However, myoinositol had fewer side effects and appeared to reduce the occurrence ovarian hyperstimulation syndrome (OHSS).


Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

First Advisor

Andvik, Vicki

Second Advisor

Solberg, Julie

Third Advisor

Larson, Annette

Publication Date

Spring 2023


Medicine and Health Sciences

Fertility Treatment in PCOS: Metformin vs. Myoinositol