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•The purpose of this literature review is to compare the use of buprenorphine-naloxone combination therapy to buprenorphine monotherapy as medication assisted therapy (MAT) for opioid dependent pregnant women.
•Outcomes compared in this study include maternal and neonatal safety, neonatal abstinence syndrome, and peripartum pain management.
•This review included electronic search databases: PubMed, Clinical Key, and Cochrane Library from September 1, 2019 to March 1, 2020. The search included randomized control trials, systematic reviews, and meta-analysis. Sources excluded included those published >25 years ago, those with poor study design, and those with primary focus on methadone.
•Current research shows evidence to support both buprenorphine monotherapy and buprenorphine-naloxone combination therapy as MAT in opioid dependent pregnant women, however at this time there is insufficient evidence to declare one therapy superior compared to the other. Many studies discuss the complications and limitations of medication trials in pregnant and opioid dependent populations.
•Ultimately, more research and clinical trials are needed in order to claim the one buprenorphine product preferable, in terms of safety and efficacy, as medication assisted therapy in pregnant women with opioid dependence.
•Key terms: buprenorphine in pregnancy, buprenorphinenaloxone in pregnancy, naloxone in pregnancy, buprenorphine safety, suboxone, Subutex, buprenorphine and neonatal abstinence syndrome, pain management buprenorphine, peripartum pain management buprenorphine.
Physician Assistant Studies
Date of Work
Buprenorphine in pregnancy, buprenorphinenaloxone in pregnancy, naloxone in pregnancy, buprenorphine safety, suboxone, Subutex, buprenorphine and neonatal abstinence syndrome, pain management buprenorphine, peripartum pain management buprenorphine.
Medicine and Health Sciences
Gillund, Ellie, "Comparison of Buprenorphine-Naloxone and Buprenorphine Monotherapy in Opioid Dependent Pregnant Women" (2020). Physician Assistant Scholarly Project Posters. 182.