Date of Award


Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)


Physician Assistant Studies

First Advisor

Julie Solberg


Human microbiome; Healthy microbiome; Systemic lupus erythematous microbiome; Immune function; Dysbiosis; Leaky gut; Autoimmune disorder microbiome


According to the National Institute of Health (NIH), it is estimated that over 24 million Americans are diagnosed with autoimmune disorders, and the cases are increasing (2005). A significant risk factor that has been linked to the formation of these diseases is the gut microbiome. The gut microbiome of the adult plays a vital role in the efficacy of the immune system. The purpose of this research and systematic literature review is to determine how the gut microbiome can influence autoimmune disorders. In this review, five databases were searched including PubMed, DynaMed, Cochrane Library, Embase, and Clinical Key. A variety of keywords and mesh terms were implemented with searching. The search time frame was limited to the previous fifteen years. Inclusion criteria included peer-reviewed journals, metaanalysis, systematic reviews, randomized controlled trials, and case studies. Exclusion criteria originally included animal studies, pediatric, or geriatric focused research. Much of the research presented shows correlations between gut dysbiosis and autoimmune disorders. Although most research does show trending data, no single definitive conclusion has been made regarding the influence of the gut microbiome and its influence on autoimmune diseases. More research still needs to be completed to possibly use gut dysbiosis as a biomarker or possible treatment tool to prevent autoimmune disorders.