Date of Award


Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)


Physician Assistant Studies

First Advisor

Russell Kauffman


Medication Assisted Treatment; Oxycodone; Heroin; Oxycodone Use Disorder; Heroin Use Disorder; Opioids; Opioid Use Disorder


The purpose of this research and systematic literature review is to determine if there is a measurable difference of effectiveness in medication assisted treatment (MAT) in patients with oxycodone and heroin use disorders, retention in treatment, and sustained sobriety. In this review, the databases searched included CINAHL, Clinical Key, and Embase. A variety of key terms and MeSH terms were used to define a set of literature discussing the topic. The works chosen for review were published between 2015 and 2019 were peer reviewed, and included randomized control trials, pilot studies, and systematic reviews. Sources that were excluded, included those published prior to the year 2015, had poor study design or no useful statistical data. For this review, 16 resources were selected. Much of the research presented show proven evidence of the efficacy and usefulness in MAT for the treatment of opioid use disorder. However, much of the research does not seem to directly compare the statistical difference in effectiveness of MAT for oxycodone and heroin use disorders, rather they are both put together in one group. The differences become apparent when adjunctive therapies are added. These therapies include; inpatient and outpatient rehabilitation, the type of medication being used, and the addition of cognitive behavioral therapy (CBT). Consequently, more research is still needed to be done in order to definitively determine if MAT is more effective for treating oxycodone use disorder or heroin use disorder.