Date of Award
Master of Physician Assistant Studies (MPAS)
Physician Assistant Studies
Varicocele, varicocelectomy, in Vitro fertilization, intracytoplasmic sperm injection, efficacy, cost effectiveness
Clinical varicoceles are the most frequent physical finding associated with infertile men and impaired semen parameters. There is evidence that suggests varicocele repair improves semen parameter and increases the chances of natural pregnancy. Today, varicocele repair is often combined with assisted reproductive techniques (ART) such as intrauterine insemination (IUI), in Vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). In this literature review, data examining whether varicocelectomy before ART leads to improved pregnancy outcomes is reviewed. Current data suggest that there is a significant clinical benefit when correcting a varicocele in oligospermic men before IVF/ICSI. Similarly, men with non-obstructive azoospermia also benefit from varicocelectomy before IVF/ICSI, but not significantly. Furthermore, in couples seeking to use ART to conceive, varicocelectomy may offer improvement in semen parameters and therefore, decrease the level of ART needed to achieve pregnancy.
Nnoli, Chukwuka Oscar, "Is a Varicocelectomy Beneficial in the Era of Assisted Reproductive Technologies?" (2019). Physician Assistant Scholarly Project Papers. 34.