Date of Award

2024

Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)

Department

Physician Assistant Studies

First Advisor

Kauffman, Russell

Abstract

In recent years, GLP-1 therapies have emerged as promising inventions for managing type 2 diabetes and obesity in adolescents. This comprehensive literature review synthesizes findings from fundamental studies, highlighting the efficacy, safety considerations, and potential variations in treatment outcomes associated with GLP-1 therapies in this demographic. The literature consistently supports the effectiveness of GLP-1 therapies, such as liraglutide, dulaglutide, and exenatide, in improving glycemic control, as evidenced by significant reductions in HbA1c levels. Additionally, these therapies often lead to favorable outcomes in terms of weight reduction, addressing a critical aspect of type 2 diabetes and obesity management in adolescents. However, safety concerns and gastrointestinal effects have been noted, emphasizing the importance of monitoring and managing potential side effects during GLP-1 therapy. Insights from studies evaluating the safety and tolerability of specific GLP-1 agents, including lixisenatide, provide valuable information for healthcare providers. While there is consensus on the general effectiveness of GLP-1 therapies, variation-specific outcomes and long-term effects remain subjects of debate. Some studies, including case-based investigations, suggest potential variations in treatment responses, necessitating further exploration and extended follow-up periods. This literature review is a practical guide for healthcare professionals, bridging the gap between research findings and clinical application. It empowers clinicians to make well-informed decisions when initiating GLP-1 therapy, considering individual patient needs and enhancing the overall quality of care for adolescents with type 2 diabetes and obesity.

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