Date of Award

Spring 2023

Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)


Physician Assistant Studies

First Advisor

Kauffman, Russell


gabapentin, alcohol use disorder, alcoholism, GABA, gabapentinoids, alcohol withdrawal, benzodiazepines, lorazepam, naltrexone, and acamprosate


The purpose of this literature review is to determine whether gabapentin is an effective treatment option for alcohol use disorder (AUD). Utilizing data sourced primarily from published clinical trials, gabapentin’s effect on heavy drinking, abstinence, withdrawal symptoms and alcohol cravings will be explored. This review will also compare gabapentin’s efficacy against currently approved AUD treatment options, along with what dosages are most efficacious while contributing the fewest adverse effects. The data presented in this literature review undeniably demonstrates a positive effect of gabapentin on alcohol use disorder; Specifically, the data shows that gabapentin at multiple dosages helps to decrease heavy drinking days (HDD), total drinking days, and alcohol cravings. Further research should be performed to evaluate whether gabapentin is more efficacious used as a monotherapy vs an additive therapy, what long term effects gabapentin has on AUD, and to define the most effective dosage and treatment duration.