Date of Award

Spring 2023

Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)


Physician Assistant Studies

First Advisor

Andvik, Vicki

Second Advisor

Kauffman, Russell


Worldwide migraines affect millions of people everyday causing significant impact on patient’s lives. Oftentimes, these patients have failed several first-line therapies for migraine prophylaxis causing pharmaceutical companies to develop newer therapies. The purpose of this systematic literature review is to evaluate the effectiveness and tolerability of transcutaneous electrical nerve stimulator (TENS) devices versus calcitonin gene related peptide (CGRP) antagonists in the application of migraine prophylaxis. PubMed and ClinicalKey were searched with key terms, 17 sources were selected that were published after 2016. Sources included meta-analysis, literature review, and randomized control trials. The data showed that TENS devices as well as CGRP antagonists were effective and safe therapy options for migraine prophylaxis. TENS devices and CGRP antagonists work on different neural pathways giving them synergistic properties when paired together. More longitudinal research needs to be conducted to further evaluate the efficacy and safety profile of long-term use of these therapy options.