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▪ Demyelinating diseases of the central nervous system are increasing in prevalence world-wide1,2 and manifest as motor, behavioral, and/or cognitive defects3 . The etiology and pathophysiology of demyelinating diseases remain unclear.

▪ We have previously observed cortical demyelination in our mouse model of non-anaphylactic cow’s milk allergy4 . The demyelination was associated with depression-like behaviors and region-specific increases in brain histamine and H3 receptor (H3R) levels4,5 .

❖ The brain’s central histaminergic system is tightly controlled and regulates many behaviors. Additionally, signaling through H3R plays a crucial role in oligodendrocyte differentiation, and thus, demyelination and remyelination6 .

▪ We hypothesized that excess histamine produced during the hypersensitivity response would influence behavior through dysregulation of the central histaminergic system, resulting in neuroinflammation and demyelination.

▪ To test our hypothesis, we treated our food allergy mouse model with thioperamide, an H3R antagonist, and examined whether blocking histaminergic signaling would ameliorate the aberrant behaviors and demyelination.

Publication Date

2023

Disciplines

Allergy and Immunology | Biological Phenomena, Cell Phenomena, and Immunity | Pathology

Cortical demyelination and depression-like behavior are associated with histaminergic dysregulation in a mouse model of peripheral inflammation
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