Date of Award

January 2025

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Qianli R. Chu

Abstract

Anemonin, a valuable cyclobutane containing dilactone is a bioactive natural product from Ranunculaceae plants. It holds great potential for applications in pharmaceuticals and materials science. However, traditional synthesis methods are hampered by low yields, toxic reagents, and environmental concerns, limiting its practical use. This study highlights the development of green and scalable synthetic strategies designed to achieve high yields while minimizing environmental impact. Our approach focuses on sustainable methodologies, including optimized steam and fractional distillation performed under mild conditions to reduce waste and energy demands. Protoanemonin’s natural ability to dimerize under mild heating offers a green approach to anemonin synthesis, eliminating the need for hazardous reagents and improving yield. Furthermore, we explore the use of renewable plant-derived feedstocks, adhering to sustainable chemistry principles and reducing dependence on fossil resources. We address cost-effectiveness and process optimization for industrial scale production. These modified, green synthetic strategies have achieved high yields of anemonin, unlocking its potential for diverse applications in an environmentally friendly and economically viable manner.

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