Date of Award


Document Type

Independent Study

Degree Name

Master of Science (MS)


This paper explores Local Anesthetic Systemic Toxicity (LAST) and the effectiveness of lipid emulsion (LE) therapy as a potential treatment modality. Regional anesthesia is a common method of anesthesia due to the significant benefits in both the perioperative and postoperative periods. LAST is a potential complication of regional anesthesia due to local anesthetic inadvertently entering the bloodstream and causing central nervous system and cardiac toxicities. Extensive research was performed through highly respected, evidence-based search engines to gather evidence of LE therapy for LAST. Through numerous animal studies, literature reviews, systematic reviews, and case reports that were reviewed to complete this paper, evidence has concluded the LE therapy is a proven effective and potentially life-saving treatment for LAST. It is, therefore, recommended that LE be included in the treatment of LAST in order to improve morbidity and mortality. The outcomes of this project improve the knowledge base of Certified Registered Nurse Anesthetists pertaining to LAST and LE therapy thus contributing to improved patient outcomes