Erik Watson,

Date of Award


Document Type

Independent Study

Degree Name

Master of Science in Nursing (MSN)


Malignant hyperthermia (MH) is a rare, life-threatening, acute hypermetobolic condition that is elicited by exposure to specific drugs used during general anesthesia. These drugs include the volatile anesthetics and the depolarizing muscle blocking antagonist. The morbidities and mortality associated with MH is significant enough that each and every anesthetic provider guards against it

Treatment and management of MH is laborious and extensive. The Malignant Hyperthermia Association of the United States (MHAUS) provides the practitioner with approp1iate treatment measures through established protocol. Dantrolene is the mainstay treatment for MH. However, the management of secondary pathologies that follow in the MH crisis requires high proficiency on the part of the anesthesia provider.

The difficulty in reconstituting dantrolene poses an issue for those health care professionals who are administering the anesthetic agents that can trigger MH. Unfortunately, there are very few published articles or case studies available that recommend a certain methodology of reconstituting dantrolene. It is the intent of this project to examine different methods of reconstitution of dantrolene utilizing readily available OR equipment.