Date of Award


Document Type

Independent Study

Degree Name

Master of Science (MS)


Major Depression Disorder is a wide spread epidemic in our country. Antidepressants are commonly prescribed by general medical practitioners as well as mental health practitioners with a low success rate ( de Jonghe, 2008). The purpose of this Independent Study was to conduct a literature review to determine if antidepressants are effective as a standalone therapy in the treatment of Major Depressive Disorder or if they have a higher success rate when used with conjunctive therapies such as cognitive therapy, exercise, and electroconvulsive therapy (ECT). An evidence based review of the literature was conducted to determine the current knowledge base regarding the effectiveness of standalone antidepressants compared to antidepressants with other therapies. It was found that antidepressants as a standalone therapy was can be as effective as it is combined with other therapies provided certain measures are being followed. The antidepressant should be indicated, and before administration, a review of the case needs to be conducted. Upon completion of the Independent Study, the information was presented to the clinical staff at South Central Human Service Centre located at Jamestown, North Dakota (see appendix A)