Date of Award


Document Type

Independent Study

Degree Name

Master of Science (MS)


The problem of postoperative nausea and vomiting (PONV) in the adult surgical patient continues to be a major source of frustration for both clinicians and surgical patients despite multiple treatment modalities available to allay this problem. PONV can cause patient anxiety in the preoperative period and discomfort in the postoperative period. Multiple pharmacological treatments have been investigated in regard to their efficacy. These treatments have been examined as both single agents and multiple agents in terms of their effectiveness in the adult surgical patient. It is desirable to establish which treatment, whether it is single agent pharmacological treatment or multiple agent pharmacological treatment, is the most effective in preventing PONV. The purpose of this independent project is to consider the efficacy of single pharmaceutical treatment modalities compared to multiple pharmaceutical treatments in preventing and treating PONV in the adult surgical patient. A review and critique of recent literature has been conducted in order to determine the best treatment for PONV. A thorough review of current literature will provide information on single pharmaceutical modalities and combination pharmaceutical modalities that contribute to lowering the risk of PONV. No one pharmacological treatment, whether it is single agent or multiple agents, has been shown to completely prevent PONV .