Date of Award
Doctor of Physical Therapy (DPT)
Aging -- physiology; Mice -- anatomy & histology; Muscle Weakness; Sarcopenia
Skeletal muscle fiber type composition has not been studied in the long-lived Ames dwarf mouse when compared to its wild-type counterpart. Hindlimb soleus skeletal muscle from two 3-month old dwarf and two 3-month old wild-type mice was analyzed for muscle fiber size, proportion of type I (slow-twitch) and type II (fast-twitch) muscle fibers, myonuclei content per muscle fiber, and total cross sectional area of the muscle. Results revealed a significant difference in muscle fiber size (t(58)=-9.71, p
Leier, Cory, "Sarcopenia and Aging: Skeletal Muscle Fiber Type Composition of the Long-Lived Ames Dwarf Mouse Compared to Its Wild-Type Counterpart" (2011). Physical Therapy Scholarly Projects. 619.