Date of Award

2011

Document Type

Scholarly Project

Degree Name

Doctor of Physical Therapy (DPT)

Department

Physical Therapy

First Advisor

Mark Romanick

Keywords

Aging -- physiology; Mice -- anatomy & histology; Muscle Weakness; Sarcopenia

Abstract

Skeletal muscle fiber type composition has not been studied in the long-lived Ames dwarf mouse when compared to its wild-type counterpart. Hindlimb soleus skeletal muscle from two 3-month old dwarf and two 3-month old wild-type mice was analyzed for muscle fiber size, proportion of type I (slow-twitch) and type II (fast-twitch) muscle fibers, myonuclei content per muscle fiber, and total cross sectional area of the muscle. Results revealed a significant difference in muscle fiber size (t(58)=-9.71, p

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