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Document Type

Poster

Description

• Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).

• Auto-inflammatory disorder occurring in affected children every 3-8 weeks.

• Onset around age 2; lasting into second decade of life.

• A current pathophysiologic theory is PFAPA is a disorder of the innate immune system involving interleukins, chemoattractants, and cytokines that stimulating the inflammatory response causing symptoms associated with PFAPA.

• Early diagnosis of PFAPA may help prevent the unnecessary use of antibiotics.

• Biomarker CD64, galectin-3 and the MPV may be useful in the diagnosis of PFAPA along with other laboratory values during the febrile attack period of PFAPA.

• Traditional and current treatment of PFAPA is single dose of corticosteroids at onset of symptoms.

• Treatment with tonsillectomy was found to have an 80% cure rate.

• No statistical difference between corticosteroid and tonsillectomy treatments.

• Treatment of PFAPA with antibiotics was found ineffective.

• Treatment of PFAPA with vitamin D, was found by one study to have promising results.

Department

Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

First Advisor

Heidi Olson-Fitzgerald

Publication Date

2015

Keywords

Fever; Pharyngitis; Stomatitis, Aphthous; Hereditary Autoinflammatory Diseases; Child

Disciplines

Infectious Disease | Pediatrics | Rheumatology

PFAPA: A Periodic Febrile Syndrome Afflicting Children

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