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• Stroke is a leading cause of disability and morbidity and the fourth leading cause of death in the United States, and the second leading cause of death worldwide.
• Early restoration of blood flow is the most effective treatment of ischemic stroke by intravenous thrombolytic therapy within 3-4.5hrs of symptom onset.
• Patient outcomes have been shown to improve with earlier thrombolytics, each 15 minute increment increases survival by 3.0-4.0%.
• Non-contrast CT is the current standard for differentiation of stroke. It is beneficial due to speed of acquisition and its high sensitivity in ruling out hemorrhagic stroke.
• However, with almost half of the US population living more than an hour from a Primary Stroke Center, the need to differentiate early in rural hospitals is increasingly important.
• The purpose of this study is to determine if biological markers like GFAP compared to CT can accurately differentiate ischemic stroke, hemorrhagic stroke, and stroke mimic.
• This literature review explores the studies that compare current biological markers in ischemic, hemorrhagic stroke, and stroke mimic, and then compares their accuracy to that of neuro imaging.
• This panel of biological markers could minimize the duration to thrombolytic therapy in patients suffering from ischemic stroke by allowing early differentiation in the rural hospital setting.
• The findings indicate that the sensitivity and specificity of a panel of biological markers, clinical judgment, and clinical tools such as NIHSS stroke scale, can approach that of the non-contrast head CT in rural setting, improving time to care and stroke recovery.
Physician Assistant Studies
Master of Physician Assistant Studies (MPAS)
Biomarkers; Neuroimaging; Stroke -- etiology; Comparative Study
Conboy, Kevin, "Serum Biomarkers Compared to Neural Imaging in the Differentiation of Stroke Etiologies" (2016). Physician Assistant Scholarly Project Posters. 67.