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• Asthma: a heterogeneous disease characterized by chronic airway inflammation resulting in respiratory difficulty.

• Bronchial Thermoplasty (BT): a bronchoscopy procedure that delivers radiofrequency energy to the tissues of airway walls thus heating the tissue, causing ablation to reduce the mass of the airway smooth muscle (ASM), hence attenuating bronchoconstriction.

• BT was designed to decrease, de-bulk or partially eliminate excess smooth muscle tissue in the distal airways, with a subsequent decrease in the number of severe asthma attacks.

• BT is an alternative treatment for patients with severe, uncontrolled asthma in which the airway smooth muscle is eliminated using radio ablation.

• In this project, several studies are presented to demonstrate the effectiveness and potential adverse impacts of BT.

• Special attention to a study performed to evaluate the safety and the effectiveness of BT in 580 asthma patients across 6 nations with symptoms despite being treated with high doses of Inhaled corticosteroid (ICS) and long acting beta agonist (LABA), the current standard of care for severe asthma.


Physician Assistant Studies

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Master of Physician Assistant Studies (MPAS)

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Asthma -- prevention & control; Bronchial Hyperreactivity -- therapy; Bronchial Thermoplasty -- adverse effects


Respiratory Tract Diseases

Effectiveness and Safety of the Bronchial Thermoplasty Procedure