Files

Download

Download Full Text (653 KB)

Document Type

Poster

Description

• Evaluate the efficacy, safety, and mechanisms of D-mannose, a natural sugar, in preventing and treating UTIs. Evidence from various studies, including randomized controlled trials and pilot research, indicates that D-mannose may reduce UTI recurrence rates and alleviate acute symptoms with comparable efficacy to standard antibiotics. • Recurrent urinary tract infections (rUTIs) are a significant health concern for women, affecting their quality of life and requiring effective and safe prophylactic and therapeutic interventions. • Daily D-mannose demonstrated a significant reduction in recurrence rates for prophylaxis compared to placebo and nitrofurantoin, with fewer adverse effects. • In acute UTI management, D-mannose-based supplements improved symptom resolution and achieved bacteriological clearance more effectively than placebo. • Mechanistically, D-mannose prevents uropathogenic Escherichia coli (UPEC) from adhering to bladder cells, interrupting infection progression without promoting bacterial resistance. • Limitations such as small sample sizes, lack of long-term follow-up, and variable study designs warrant further large-scale, blinded trials to establish standardized dosing regimens and confirm efficacy. • D-mannose represents a potential alternative or adjunct in UTI management, emphasizing a need for continued research into its clinical applications.

Department

Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

Date of Work

2025

Publication Date

Spring 5-2025

Disciplines

Medicine and Health Sciences

D-Mannose Efficacy in Preventing Recurrent Urinary Tract Infections in Women

Share

COinS