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Document Type
Poster
Description
• Evaluate the efficacy, safety, and mechanisms of D-mannose, a natural sugar, in preventing and treating UTIs. Evidence from various studies, including randomized controlled trials and pilot research, indicates that D-mannose may reduce UTI recurrence rates and alleviate acute symptoms with comparable efficacy to standard antibiotics. • Recurrent urinary tract infections (rUTIs) are a significant health concern for women, affecting their quality of life and requiring effective and safe prophylactic and therapeutic interventions. • Daily D-mannose demonstrated a significant reduction in recurrence rates for prophylaxis compared to placebo and nitrofurantoin, with fewer adverse effects. • In acute UTI management, D-mannose-based supplements improved symptom resolution and achieved bacteriological clearance more effectively than placebo. • Mechanistically, D-mannose prevents uropathogenic Escherichia coli (UPEC) from adhering to bladder cells, interrupting infection progression without promoting bacterial resistance. • Limitations such as small sample sizes, lack of long-term follow-up, and variable study designs warrant further large-scale, blinded trials to establish standardized dosing regimens and confirm efficacy. • D-mannose represents a potential alternative or adjunct in UTI management, emphasizing a need for continued research into its clinical applications.
Department
Physician Assistant Studies
Degree Name
Master of Physician Assistant Studies (MPAS)
Date of Work
2025
Publication Date
Spring 5-2025
Disciplines
Medicine and Health Sciences
Recommended Citation
Lee, Miah, "D-Mannose Efficacy in Preventing Recurrent Urinary Tract Infections in Women" (2025). Physician Assistant Scholarly Project Posters. 323.
https://commons.und.edu/pas-grad-posters/323