Efficacy of Low-dose Naltrexone Compared to Gabapentinoids in Fibromyalgia

Authors

Dillon Boen, University of North Dakota

Files

Document Type

Poster

Description

• . This literature review evaluates the efficacy, safety, and tolerability of low-dose naltrexone (LDN) compared to gabapentinoids, including gabapentin and pregabalin, in the management of fibromyalgia symptoms. • Pilot studies on LDN highlighted its potential anti-inflammatory benefits and its ability to reduce pain severity and improve quality of life, with minimal side effects. Gabapentinoids demonstrated dose-dependent efficacy in pain reduction and sleep quality improvement but had adverse effects, including dizziness and sedation, which may limit their tolerability. • The findings underscore the need for more extensive, long-term research to confirm the therapeutic potential of LDN and refine the clinical use of gabapentinoids in fibromyalgia management.

Department

Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

Date of Work

2025

Publication Date

Spring 5-2025

Disciplines

Medicine and Health Sciences

Recommended Citation

Boen, Dillon, "Efficacy of Low-dose Naltrexone Compared to Gabapentinoids in Fibromyalgia" (2025). Physician Assistant Scholarly Project Posters. 314.
https://commons.und.edu/pas-grad-posters/314