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Sebaceous carcinoma (SC) has its origin in the sebaceous glands of the dermis and may develop as a result of de novo mutations from benign sebaceous neoplasms or as a result of microsatellite instability and loss of mismatch repair gene expression secondary to Muir-Torre Syndrome (MTS). SCs may also arise from the Meibomian glands, the glands of Zeis, or the sebaceous glands of the caruncle if occurring periocularly. Although SCs may occur at any sebaceous gland-containing location, the most common areas of involvement include the periocular, head, and neck regions. Given its capacity for nodal and distal metastasis as well as its association with significant morbidity and mortality, surgical excision must be pursued. The high recurrence rate and tendency of misdiagnosis that are associated with SCs, warrant swift diagnostic measures and the establishment of a gold-standard method of surgical treatment. Therefore, the purpose of this literature review is to compare the efficacies of MMS and WLE in the prevention of recurrence and metastasis of both extraocular and ocular SCs.


Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

Date of Work


First Advisor

Kauffman, Russell

Publication Date

Spring 2024


Medicine and Health Sciences

Sebaceous Carcinoma: A Commitment to a Standard of Care