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Pre-eclampsia is a hypertensive disorder that occurs during pregnancy. Onset is typically around the 20 week of gestation and serious complications may occur if it is not properly managed. Complications from pre-eclampsia include preterm delivery, disease progression to eclampsia, organ damage, placental abruption, and neonatal complications. Initial management involves the use of antihypertensive medications. Current guidelines recommend the initiation of 81 mg aspirin starting at 12 weeks gestation for women with increased risk factors. The goal of this literature review is to examine the effectiveness of calcium and vitamin D supplementation compared to daily prophylactic aspirin use for prevention of pre-eclampsia. The databases utilized for this literature review include Pub-Med, Cochrane Library, Clinical Key, and Google Scholar. Additional relevant studies were found in reference lists of the included studies. This comprehensive review will discuss initiation of therapy, dosing, and pregnancy outcomes. Review of the literature showed a decrease in blood pressure with the use of calcium and vitamin D supplementation. However, there was a greater impact shown with calcium supplementation in populations with a dietary deficiency than those without a dietary deficiency in calcium. The effect of 150 mg daily prophylactic aspirin was shown to reduce the occurrence of preterm pre-eclampsia but did not impact preeclampsia after 37 weeks of gestation.


Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

Date of Work


First Advisor

Carr, Kristen

Publication Date

Spring 2024


pre-eclampsia, aspirin, calcium supplementation, vitamin D supplementation, blood pressure, hypertensive disorders, pregnancy


Medicine and Health Sciences

Does Supplementation with Vitamin D and Calcium Reduce the Risk of Developing Pre-eclampsia Compared with Prophylactic Daily Aspirin Use?