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• Chronic obstructive pulmonary disease (COPD) is a progressive disease that has no cure but is treatable. The treatment goal is to have adequate symptom control, decreased exacerbations, prevent hospitalizations and maintain an independent quality of life.
• The review of literature is to determine if the benefits of long-term antimicrobial therapy outweigh the risks in the treatment of severe COPD.
• The gold standard for pharmacotherapy consists of inhaled corticosteroids and bronchodilators (long-acting beta2agonist (LABA).
• Adding azithromycin to standard therapy for patients with frequent exacerbations showed a 27% reduction in exacerbation frequency.
• With prolonged use of antimicrobials there is an increased risk of bacterial resistance. However, in doing this research, it was found that bacterial resistance was not noticed between azithromycin (52%) versus placebo (57%), p = 0.64.
• Although long-term antimicrobial therapy is becoming a hot topic, it is imperative that we continue to study the detrimental development of bacterial resistance.
Physician Assistant Studies
Master of Physician Assistant Studies (MPAS)
chronic obstructive pulmonary disease; antibiotics; macrolides; antibacterial; azithromycin; bronchodilators; standard therapy; COPD exacerbations; adverse effects
Trautner, Jamie, "Antibiotic Therapy in Preventing Exacerbations of Severe Chronic Obstructive Pulmonary Disease" (2018). Physician Assistant Scholarly Project Posters. 27.