Files

Download

Download Full Text (445 KB)

Document Type

Poster

Description

• Chronic obstructive pulmonary disease (COPD) is a progressive disease that has no cure but is treatable. The treatment goal is to have adequate symptom control, decreased exacerbations, prevent hospitalizations and maintain an independent quality of life.

• The review of literature is to determine if the benefits of long-term antimicrobial therapy outweigh the risks in the treatment of severe COPD.

• The gold standard for pharmacotherapy consists of inhaled corticosteroids and bronchodilators (long-acting beta2agonist (LABA).

• Adding azithromycin to standard therapy for patients with frequent exacerbations showed a 27% reduction in exacerbation frequency.

• With prolonged use of antimicrobials there is an increased risk of bacterial resistance. However, in doing this research, it was found that bacterial resistance was not noticed between azithromycin (52%) versus placebo (57%), p = 0.64.

• Although long-term antimicrobial therapy is becoming a hot topic, it is imperative that we continue to study the detrimental development of bacterial resistance.

Department

Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

Publication Date

2018

Keywords

chronic obstructive pulmonary disease; antibiotics; macrolides; antibacterial; azithromycin; bronchodilators; standard therapy; COPD exacerbations; adverse effects

Disciplines

Pulmonology

Antibiotic Therapy in Preventing Exacerbations of Severe Chronic Obstructive Pulmonary Disease

Included in

Pulmonology Commons

Share

COinS