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Methamphetamine use is a relevant problems in many communities. While it has many adverse health effects, it may also contribute to the development of the neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Parkinson’s disease (PD).
• A literature review was conducted using PubMed, EMBASE, Clinical Key, and DynaMed. Literature found included high quality systematic reviews, randomized controlled trials, and meta-analysis.
• Literature supports that METH use has several major neurotoxic effects resulting in physical and cognitive deficits. There is minimal available evidence evaluating METH use as a risk factor for ALS although, they do share a common pathway for neurotoxicity. METH use does not appear to be a risk factor for developing MS but can be a mimicker. METH is a risk factor for developing PD.
Physician Assistant Studies
Date of Work
Methamphetamine, neurodegeneration, neurotoxicity, MRI, multiple sclerosis, Parkinson’s disease, amyotrophic lateral sclerosis, attenuation, structural changes
Medicine and Health Sciences
Sarlette, Katelyn, "Methamphetamine: Potential Risk Factor for Neurodegenerative Conditions" (2020). Physician Assistant Scholarly Project Posters. 222.