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The purpose of this research and literature review was to analyze the safety and efficacy associated with invasive catheter ablation of the accessory pathway, in comparison to risk of sudden cardiac death and malignant arrythmias in non-ablated, asymptomatic individuals with Wolff-Parkinson-White (WPW). In this review, five databases were searched including CINAHL, Clinical Key, PubMed, Cochrane Library, and Dynamed Plus. Both keyword and mesh terms were used to define a set of the literature discussing Wolff-Parkinson-White, ventricular preexcitation, radiofrequency catheter ablation, and sudden cardiac death. Works chosen for review were published from 2009 to 2019, and included surveys, case control studies, and cohort studies. Much of the research suggests that electrophysiologists do not currently have an adequate evidence-based recommendation for the management of the asymptomatic patient with WPW. The methodology and safety of the ablation procedures may have evolved over time, making it difficult with the current data available to conclude the safety and efficacy of modern radiofrequency catheter ablation. Research also appears to be lacking longitudinal studies analyzing the outcomes of the non-ablated individuals. Future research is necessary to develop a guideline to direct decision to ablate the asymptomatic patient according to predetermined criteria and patient factors.
Physician Assistant Studies
Date of Work
Syndrome, Wolff-Parkinson-White (WPW), accessory pathway (AP), atrioventricular node, ventricular preexcitation, WPW pattern, WPW syndrome, radiofrequency catheter ablation.
Medicine and Health Sciences
Mondry, Erin B., "Catheter Ablation of the Accessory Pathway in the Asymptomatic Patient with Wolff-Parkinson-White" (2020). Physician Assistant Scholarly Project Posters. 210.