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To determine if letrozole is an equal or better alternative to clomiphene citrate for infertility treatment in PCOS patients.
Letrozole was found to have higher ovulation rates, fewer twin pregnancies/more single births, higher pregnancy rates, and higher live birth rates compared to clomiphene citrate. There were conflicting results for endometrial thickness and single follicle stimulation. Neither letrozole or clomiphene citrate was superior to the other for ovarian hyperstimulation syndrome. There were no significant differences between letrozole and clomiphene citrate regarding congenital abnormalities and miscarriage rates. The results regarding ectopic pregnancies were comparable between both groups.
The results provide information supporting letrozole as an adequate first-line alternative to clomiphene citrate for infertility in patients with PCOS.
Physician Assistant Studies
Master of Physician Assistant Studies (MPAS)
infertility treatment; PCOS; letrozole; clomiphene citrate; safety; femara; clomid
Endocrine System Diseases
Potratz, Kailey, "Letrozole vs. Clomiphene Citrate for Infertility in Polycystic Ovarian Syndrome" (2018). Physician Assistant Scholarly Project Posters. 21.