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The purpose of this literature review is to determine the efficacy and safety of pharmacologic treatments for orthostatic hypotension (OH), with an emphasis on researching the elderly population. In this review, three electronic search databases were utilized including PubMed, Google Scholar, and Dynamed from the years 1997 to 2019. Several keywords were used during the search. The specific pharmacologic agents researched for the treatment of OH included midodrine, droxidopa, pyridostigmine, and fludrocortisone. Although midodrine is the most researched and utilized pharmacologic treatment of OH, this drug may not be the best option when it comes to treatment in the elderly population due to an increase in supine hypertension. Pyridostigmine in combination with low-dose midodrine was found to be effective in relieving OH symptoms without increasing supine hypertension, but this evidence is based on limited randomized trials. More research is needed in order to evaluate the efficacy and safety of these pharmacologic measures in the treatment of OH specifically in the elderly population and over a long period of time.
Physician Assistant Studies
Date of Work
Orthostatic Hypotension (OH), elderly, supine hypertension, midodrine, droxidopa, pyridostigmine, and fludrocortisone.
Medicine and Health Sciences
Moeller, Abigail, "Efficacy of Pharmacologic Treatment for Orthostatic Hypotension in the Elderly Population" (2021). Physician Assistant Scholarly Project Posters. 209.