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Male obesity-related secondary hypogonadism (MOSH) is often underdiagnosed in the young male population.
The current standard of care for hypogonadism in the older male population typically includes testosterone replacement therapy (TRT).
• The purpose of this study is to highlight available treatment options for MOSH in the younger population and the various effects on fertility.
• The method utilized was a systematic review of the current literature that targeted studies of obese males below the age of 65 treated for secondary hypogonadism.
• This review highlights some of the current recommendations, including lifestyle changes, and compares the use of TRT and selective estrogen receptor modulators (SERMs) and the effects on reproductive health.
• Promisingly, SERMs were found to be more protective of sperm production than traditional testosterone replacement.
Physician Assistant Studies
Date of Work
Male obesity, MOSH, and testosterone levels
Medicine and Health Sciences
Harmon, Julie, "Treatment of MOSH and the Effects on Fertility" (2021). Physician Assistant Scholarly Project Posters. 184.