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Asthma is a chronic, non-curable respiratory disease that has multi-factorial effects on the bronchial mucosa. Despite optimal prevention and standardized first line asthma care the symptoms can deteriorate leading into an asthma exacerbation which is a medical emergency. Purpose:
• To determine the efficacy of ketamine use as an adjunctive medication for acutes severe asthma exacerbations that had failed standard guideline directed treatments. Methods: • Relevant databases were searched looking for ketamine use in asthma exacerbations.
• The inclusion material consists of pediatric and adult populations in available systematic reviews, randomized control trials, meta-analysis, pilot studies, case reports, and peer-reviewed journal articles. Findings:
• Preliminary results showed no positive outcomes of improvement in asthma symptoms with low dose ketamine.
• Several findings point to noteworthy positive outcomes with an intravenous ketamine high dissociative dosing administration.
• In a small case report the use of nebulized ketamine showed promise at reversing the airway obstruction promptly. Implications:
• Some experts feel strongly that the dose ranges and duration of treatment play a key role into the efficacy of ketamine used as a pharmacological option.
• More research is needed with larger, high quality, randomized studies that addresses and objectively measures varying dosage regimens to form a consensus on the efficacy of ketamine use in refractory asthma exacerbations.
Physician Assistant Studies
Date of Work
: Asthma, acute asthma exacerbation, asthma standardized practice guidelines, ketamine, ketamine in asthma exacerbations, severe asthma, status asthmaticus
Medicine and Health Sciences
Frentzel, Stephanie, "Ketamine in Refractory Asthma Exacerbations" (2021). Physician Assistant Scholarly Project Posters. 179.