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According to the National Institute of Health (NIH), it is estimated that over 24 million Americans are diagnosed with autoimmune disorders, and the cases are increasing (2005). A significant risk factor that has been linked to the formation of these diseases is the gut microbiome. The gut microbiome of the adult plays a vital role in the efficacy of the immune system. The purpose of this research and systematic literature review is to determine how the gut microbiome can influence autoimmune disorders. In this review, five databases were searched including PubMed, DynaMed, Cochrane Library, Embase, and Clinical Key. A variety of keywords and mesh terms were implemented with searching. The search time frame was limited to the previous fifteen years. Inclusion criteria included peer-reviewed journals, meta-analysis, systematic reviews, randomized controlled trials, and case studies. Exclusion criteria originally included animal studies, pediatric, or geriatric focused research. Much of the research presented shows correlations between gut dysbiosis and autoimmune disorders. Although most research does show trending data, no single definitive conclusion has been made regarding the influence of the gut microbiome and its influence on autoimmune diseases. More research still needs to be completed to possibly use gut dysbiosis as a biomarker or possible treatment tool to prevent autoimmune disorders.


Physician Assistant Studies

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Gut Microbiome, Autoimmune Disorders, bowel-related diseases, gastrointestinal tract, dysbiosis


Medicine and Health Sciences

The Role of the Gut Microbiome in Autoimmune Disorders