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With the high incidence of Lyme disease in the endemic areas of North America, it is important to appropriately diagnosis and treat this condition to prevent post treatment Lyme disease syndrome (PTLDS). Background information regarding Lyme disease is given. The purpose of this research is to discuss the treatment options available for those patients that fit the case definition of PTLDS. A literature review was conducted using several different electronic databases finding peer reviewed research articles pertaining to the treatment options available for PTLDS. Extended antibiotic use is shown to be not beneficial in most cases. Alternative treatment options listed on the internet are shown to be not evidence based. Therefore, symptomatic treatment options seem to be the best positive outcome-based option available for providers to use. These options are discussed in detail throughout this research. Though much more research is needed regarding the topic, this will give providers the information currently available that they will need to know when treating patients with PTLDS. Hopefully this will provide the patients with PTLDS the best outcome possible for improving their quality of life post Lyme disease.


Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

First Advisor

Russell Kauffman

Publication Date



Infectious Disease

Treatment Options for Post Treatment Lyme Disease Syndrome