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Cystic fibrosis is an autosomal recessive genetic disorder that severely affects the lungs as well as other organs in the body. The pathophysiology of cystic fibrosis lung disease involves the production of thick and sticky mucus that accumulates leading to obstruction and inflammation of the airways. This disease is characterized by abnormal transport of sodium and chloride across an epithelium by defective genes, resulting in thick mucus secretions.

Nebulized hypertonic saline (3% NaCl) improves mucociliary clearance through rehydration of the airway surface liquid of the lungs. The purpose of this study is to evaluate the effects of nebulized hypertonic saline in improving lung function and decreasing exacerbation rates in older children (10-18 years of age) and adults with stable cystic fibrosis compared to normal saline (0.9%).

The review of literature will focus on comparing the use of nebulized hypertonic saline in enhancing mucociliary clearance in CF patients compared to other methods. The expected outcome is that nebulized hypertonic saline treatment will improve lung function and decrease exacerbation of CF in these groups.


Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

First Advisor

Vikki McCleary

Second Advisor

Susan Kuntz

Publication Date



Adolescent; Child; Cystic Fibrosis -- drug therapy; Mucociliary Clearance -- drug effects; Saline Solution, Hypertonic -- therapeutic use; Comparative Study


Respiratory Tract Diseases

Hypertonic Saline Therapy in Cystic Fibrosis