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• Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal Infection, known as PANDAS, is a clinical diagnosis made after a child develops Obsessive Compulsive Disorder and/or ticks after a Streptococcal Pharyngitis. Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal Infection is diagnosed in children 3 years of age until 14 years of age. The purpose of this study is to determine if antibiotics versus selective serotonin reuptake inhibitor with cognitive behavior therapy versus prophylaxis with antibiotics should be used in the treatment of children who develops PANDAS. The review of literature will explore studies that compare current treatment options with new research and alternate treatment options. The researcher plans to analyze the data of these studies to better enhance treatment options for children diagnosed with PANDAS. The lack of knowledge and understanding of the diagnosis will allow providers to get a better understanding of the diagnosis and the best possible treatment. It’s anticipated that the best treatment for children diagnosed with PANDAS is antibiotic treatment for positive rapid strep test or positive Antistreptolysin O titers. The findings may indicate that health care providers need more education on PANDAS and treatment. Pediatricians along with mid-level providers should evaluate and diagnose any children with a positive ASO titer who has developed OCD with PANDAS. These children should be re-evaluated within four weeks to assess response to treatment.


Physician Assistant Studies

Degree Name

Master of Physician Assistant Studies (MPAS)

First Advisor

Vikki McCleary

Publication Date



Antibiotic Prophylaxis; Azithromycin -- therapeutic use; Child; Child, Preschool; Obsessive-Compulsive Disorder -- drug therapy; Penicillins -- therapeutic use; Streptococcal Infections -- drug therapy; Tic Disorders -- drug therapy; Treatment Outcome; Comparative Studies


Neurology | Pediatrics | Psychiatric and Mental Health

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection Antibiotic Prophylaxis Treatment Compared With Alternative Treatment Options