Date of Award

Spring 5-2025

Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)

Department

Physician Assistant Studies

First Advisor

Kauffman, Russ

Keywords

adult, blood glucose, Diabetes Mellitus, Type 2 diabetes, drug therapy and insulin

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or a combination of both. The purpose of this literature review is to determine if patients with diabetes mellitus taking once weekly insulin injections compared to once daily insulin injections offer the same, or better, effectiveness at lowering their HbA1c. This is critical in the management and progression of the disease. The electronic databases PubMed, Clinical Key and Embase were searched and there were 92 articles found. Inclusion criteria included articles published within the past 5 years, randomized clinical trials and meta-analysis. Seven studies met final criteria for inclusion. Review of the included literature supports the use of once weekly insulin as it has similar efficacy to once daily insulin in reducing HbA1c. Future research could be conducted to study once weekly insulin in individuals for a longer amount of time, since the once weekly insulin is new. Diabetes comes with many other comorbidities so research could also be conducted in individuals that have secondary comorbidities to diabetes.

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