Date of Award

Spring 5-2025

Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)

Department

Physician Assistant Studies

First Advisor

Kauffman, Russ

Keywords

Attention-Deficit/Hyperactivity Disorder (ADHD), multinutrient supplementation, gut microbiome, gut-brain axis, children ages 6-12

Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent neuropsychiatric condition affecting children, often characterized by inattention, hyperactivity, and impulsivity. Recent evidence suggests a potential link between gut microbiota composition and neuropsychiatric disorders, including ADHD, through the gut-brain axis (GBA). A literature review of studies published between 2017 and 2024 explores the efficacy of multinutrient interventions on influencing gut microbiota to treat the core symptoms of ADHD in children ages 6-12 years old. Findings indicate that multinutrient supplementation may modulate gut microbiota and subsequently impact neuropsychiatric symptoms, offering a promising adjunctive treatment for ADHD. However, variability in study methodologies and small sample sizes highlight the need for further research to establish conclusive evidence and practical clinical applications.

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