Date of Award

Spring 5-2025

Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)

Department

Physician Assistant Studies

First Advisor

McHugo, Jeanie

Keywords

non-steroidal anti-inflammatory agents, NSAIDs, orthopedics, surgery, bone, fracture and healing

Abstract

Use of NSAIDs in adults recovering from orthopedic injury or surgery has been found to be largely inconclusive when it comes to determining significance in delay of bone healing. The purpose of this review is to determine whether use of NSAIDs is detrimental to bone healing after orthopedic injury or surgery. A literature review was performed using electronic databases PubMed and SportsDiscus from May to July of 2024. There were fifteen studies that met final inclusion criteria. Research overwhelmingly acknowledged that selective COX-2 inhibitors are not recommended in a post injury or post operative state. However, when it comes to nonselective COX inhibitors, there is no definitive answer. Future research should focus on larger sample sizes, more randomized controlled trials, use of more in vivo/ in vitro study models and effects of specific NSAIDs. Investigations should also include all ages, genders, and races. The focus of initial research should be placed on otherwise healthy individuals with no known medical conditions. Subsequent studies should compare initial outcomes against individuals with the most common comorbidities and continue to grow the population outward.

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