Date of Award


Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)


Physician Assistant Studies

First Advisor

Daryl Sieg

Second Advisor

Mindy Stavetig


GERD; Gastroesophageal reflux disease; Pharmacotherapeutics; Surgery; Heartburn; and PPI


The purpose of this systematic review is to explore the efficacy of pharmacotherapeutics and surgical interventions for the treatment of gastroesophageal reflux disease (GERD). In this systematic review, five electronic databases were used including AccessMedicine, PubMed, Cochrane library, Dynamed, and Clinical Key. Research criteria included work after 2010, peer reviewed, and only randomized control trials, systematic reviews, and meta-analyses were considered. Studies that were excluded included any that were before 2010, poor study design, and those that looked at other conditions or treatments outside of the research question in study. A total of 9 studies were selected for this systematic review. The research clearly shows benefits for both pharmacotherapy and surgical intervention for the treatment of GERD. The studies have shown a mixture of results when it comes to which treatment is more efficacious. Although both treatments have been shown to be effective, more research needs to be done to clearly identify risks and benefits of the different types of GERD treatments.