Date of Award


Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)


Physician Assistant Studies


Type 1 Diabetes Mellitus; T1DM; pathophysiology; continuous glucose monitoring; closed loop insulin delivery; artificial pancreas; glycemic control; hypoglycemia; insulin dependent; diabetes control and complications trial; DCCT


As of 2015, 9.4% of the US population had a diagnosis of Diabetes Mellitus (DM). Although most of the data sets studied encompass type 1 (T1) and type 2 (T2) DM data in all ages of patients, the focus of this project will be primarily on T1DM patients. A thorough review of the current literature reveals that there are effective methods currently available for the management of T1DM patients. These methods include: closed-loop insulin pumps that integrate a continuous glucose monitor (CGM) and insulin pump into one effective system that calculates the needed insulin doses through complicated algorithms, CGM with self-blood glucose monitoring calibrations (SBGM) and insulin administration, and SBGM with insulin administration. Even though these individual methods have their associated challenges, the literature reveals that closed-loop insulin pumps have the potential to provide better disease management and improved disease outcomes for those patients who are motivated to use them as directed and find them a desirable option. When patients can effectively manage their blood glucose, and practice healthy lifestyle and dietary choices, they can avoid unnecessary hospitalizations and long-term diabetic complications. This will simultaneously reduce healthcare-related costs, increase longevity and can improve the patient’s quality of life.