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▪ Food allergy is often comorbid with neuropsychiatric disorders such as anxiety1,2, depression1,2, OCD3, ADD/ADHD4, and autism5. ➢ The mechanism of how food allergy may impact brain function and behavior in certain allergic individuals has yet to be elucidated.

▪ Mast cells (MCs) are not only the effector cell of the hypersensitivity response but are also important in maintaining brain homeostasis6. ➢ MCs have been implicated in neuropsychiatric and neurodegenerative disorders such as multiple sclerosis7,8.

▪ We have previously found in a mouse model of cow’s milk allergy (CMA) that intracranial MC numbers9 and histamine 3 receptor (H3R)10 increased after acute allergic challenge in association with neuroinflammation and behavioral changes.

▪ We hypothesized that upon exposure to an allergen, MC-derived histamine would cause dysregulation of the brain’s histaminergic system, increasing neuroinflammation and altering behavior.

▪ To test our hypothesis, we preformed two studies using our mouse model of non-anaphylactic CMA to 1) observe changes in behavior and brain pathophysiology and 2) determine the role of excess histamine in our mouse model in the development of aberrant behaviors.

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Allergy and Immunology | Biological Phenomena, Cell Phenomena, and Immunity | Pathology

Repeated allergen exposure induces histaminergic dysregulation and depression-like behaviors in a non-anaphylactic food allergy mouse model