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▪ Food allergy is often comorbid with neuropsychiatric disorders such as anxiety1,2, depression1,2, OCD3, ADD/ADHD4, and autism5. ➢ The mechanism of how food allergy may impact brain function and behavior in certain allergic individuals has yet to be elucidated.
▪ Mast cells (MCs) are not only the effector cell of the hypersensitivity response but are also important in maintaining brain homeostasis6. ➢ MCs have been implicated in neuropsychiatric and neurodegenerative disorders such as multiple sclerosis7,8.
▪ We have previously found in a mouse model of cow’s milk allergy (CMA) that intracranial MC numbers9 and histamine 3 receptor (H3R)10 increased after acute allergic challenge in association with neuroinflammation and behavioral changes.
▪ We hypothesized that upon exposure to an allergen, MC-derived histamine would cause dysregulation of the brain’s histaminergic system, increasing neuroinflammation and altering behavior.
▪ To test our hypothesis, we preformed two studies using our mouse model of non-anaphylactic CMA to 1) observe changes in behavior and brain pathophysiology and 2) determine the role of excess histamine in our mouse model in the development of aberrant behaviors.
Allergy and Immunology | Biological Phenomena, Cell Phenomena, and Immunity | Pathology
Germundson-Hermanson, Danielle, "Repeated allergen exposure induces histaminergic dysregulation and depression-like behaviors in a non-anaphylactic food allergy mouse model" (2023). Biomedical Sciences Posters and Presentations. 5.