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Background Histamine is best known for causing allergy symptoms, but it also regulates blood-brain barrier permeability1 and oligodendrocyte differentiation2. Thus, brain histamine levels are tightly controlled.

Previous Findings We demonstrated that histamine and histamine H3 receptor (H3R) levels were elevated in a mouse model of cow’s milk allergy (CMA) in association with intracranial mast cell activation, depression-like behaviors, and cortical demyelination3,4.

Gaps in Knowledge In humans, food allergies are often associated with neuropsychiatric disorders5-7, but the involvement of allergy induced histamine in triggering behavioral changes is unclear.

Hypothesis Repeated allergen consumption can lead to central histaminergic dysfunction through H3R, ultimately resulting in cortical demyelination and aberrant behaviors.

Study Objectives We aimed to elucidate if antagonizing H3R could improve the behavioral and neuropathological outcomes in our mouse model after induction of CMA with repeated dietary allergen exposure.

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Allergy and Immunology | Biological Phenomena, Cell Phenomena, and Immunity | Pathology

Histamine H3 receptor antagonism mitigates food-hypersensitivity-associated depressive behavior and neuropathology in a mouse model of cow’s milk allergy