Document Type
Article
Publication Date
12-2015
Publication Title
Nature Communications
Volume
6
Abstract
A widely appreciated aspect of developmental robustness is pattern formation in proportion to size. But how such scaling features emerge dynamically remains poorly understood. Here we generate a data set of the expression profiles of six gap genes in Drosophila melanogasterembryos that differ significantly in size. Expression patterns exhibit size-dependent dynamics both spatially and temporally. We uncover a dynamic emergence of under-scaling in the posterior, accompanied by reduced expression levels of gap genes near the middle of large embryos. Simulation results show that a size-dependent Bicoid gradient input can lead to reduced Krüppel expression that can have long-range and dynamic effects on gap gene expression in the posterior. Thus, for emergence of scaled patterns, the entire embryo may be viewed as a single unified dynamic system where maternally derived size-dependent information interpreted locally can be propagated in space and time as governed by the dynamics of a gene regulatory network.
DOI
10.1038/ncomms10031
ISSN
2041-1723
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Honggang Wu, Renjie Jiao, Manu, et al.. "Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila" (2015). Biology Faculty Publications. 2.
https://commons.und.edu/bio-fac/2