Document Type

Article

Publication Date

10-2011

Publication Title

Alzheimer Disease & Associated Disorders

Volume

25

Abstract

We compared patterns of neuropsychiatric symptoms across 4 dementia types [Alzheimer disease (AD), vascular dementia (VAD), dementia with Lewy bodies (DLB), and Parkinson disease dementia], and 2 mixed groups (AD/VAD and AD/DLB) in sample of 2,963 individuals from the National Alzheimer's Coordinating Center Uniform Data Set between September 2005 and June 2008. We used confirmatory factor analysis to compare neuropsychiatric symptom severity ratings made by collateral sources on the Neuropsychiatric Inventory Questionnaire for people with Clinical Dementia Rating scores of 1 or higher. A 3-factor model of psychiatric symptoms (mood, psychotic, and frontal) was shared across all dementia types. Between-group comparisons revealed unique neuropsychiatric profiles by dementia type. The AD group had moderate levels of mood, psychotic, and frontal symptoms whereas VAD exhibited the highest levels and Parkinson disease dementia had the lowest levels. DLB and the mixed dementias had more complex symptom profiles. Depressed mood was the dominant symptom in people with mild diagnoses. Differing psychiatric symptom profiles provide useful information regarding the noncognitive symptoms of dementia.

Issue

4

First Page

326

Last Page

332

DOI

10.1097/WAD.0b013e31820d89b6

ISSN

1546-4156

Rights

This is a non-final version of an article published in final form in:

Johnson, David K., et al. “Neuropsychiatric Profiles in Dementia.” Alzheimer Disease & Associated Disorders, vol. 25, no. 4, Dec. 2011, pp. 326–32. DOI:10.1097/WAD.0b013e31820d89b6.

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