Date of Award

2024

Document Type

Scholarly Project

Degree Name

Master of Physician Assistant Studies (MPAS)

Department

Physician Assistant Studies

First Advisor

Solberg, Julie

Keywords

Parkinson disease, MIND diet, Mediterranean diet, DASH diet, Levodopa, dopamine agonists, monoamine oxidase B inhibitors, ropinirole

Abstract

Parkinson disease is multifactorial, and predominantly affects the geriatric population. The mainstay of treatment for patients diagnosed with Parkinson disease is currently symptomatic treatment with dopamine replacement. The goal of this literature review is to identify possible lifestyle modifications that can delay progression of the disease or help prolong OFF time of symptoms. Lifestyle modification predominantly considered during this review included diet and physical activity. Included in the study were MIND, Mediterranean, and DASH diets. Considering the role of medication in this disease levodopa, dopamine agonists, monoamine oxidase B inhibitors and the addition of ropinirole to levodopa and their efficacy in treating parkinsonian symptoms was investigated. A literature review was conducted using electronic search databases including, PubMed, Clinical Key and DynaMed. After thorough review of 12 articles regarding management of Parkinson disease with various modifications along with medications, it was found lifestyle modifications are not significant in the management of Parkinson disease alone. However, there is evidence to support the benefits lifestyle modifications can have, including diet and physical activity, for those diagnosed with Parkinson disease. The addition of these changes have shown the possibility of reducing the OFF time in the disease as well as reducing the daily medication regimen needed.

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